TNF and polycystic ovary syndrome: We found that PCOS patients will face the problems of long COH time, high Gn dosage, low high-quality embryo rate, low clinical pregnancy rate, and high abortion rate during IVF-ET, but TNF-α inhibitors help to improve high-quality embryo rate, clinical pregnancy rate, days of Gn use, total Gn dosage, trigger time, sex hormones on the day of HCG injection.