Deleterious germline mutations of at last 15 genes (BRCA1/2, ATM, BARD1, CDH1, CDKN2A, CHEK2, MLH1, MSH2, MSH6, NF1, PALB2, PTEN, RAD51D, TP53, BRIP1) are associated with an increased risk (> 2.0 times) of breast cancer. The gene discussed is BRCA1; the disease is breast carcinoma.