The transcription regulator Non-POU domain-containing octamer-binding protein [49] as well as the cytokine IFN-alpha-2 (IFNA2) and its receptor IFNAR were also upstream regulators in patients progressing to DHF, with several genes involved in stress response and inflammatory processes predicted as targets in these type I IFN-mediated pathways (Fig. 5E). This evidence concerns the gene NONO and Dengue hemorrhagic fever.