Similar to our findings here, progression to severe dengue has been shown to be often [52, 53, 57, 59, 67–69] but not always [54, 58, 61, 70] associated with transcriptional signatures featuring NK cell activation, increased apoptosis, upregulation of type I interferon and IFN-γ-mediated pathways. This evidence concerns the gene IFNG and dengue disease.