Upstream regulator and graphical summary analysis predicted key transcription factors involved in the control of cell division such as MYC, FOXM1 and FOXO1, as well as T cell activation molecules (CD3, CD40, and CD28) as key elements responsible for these transcriptional signatures, suggesting that these pathways could become preferentially activated in individuals who progressed to mild DF (Fig. 5D, G). Here, CD28 is linked to dengue disease.