tSNE analysis and FlowSOM clustering of the CD19+CD20+CD10− MBC pool facilitated the identification of five classical and three atypical MBC sub-populations, including populations of both IgM+IgD+ and class-switched (IgM−IgD−) cells expressing variable levels of the chemokine receptors CCR6, CCR7, CXCR3 and CXCR5 (Fig. 2F), present in the blood of dengue patients at first presentation. The gene discussed is CXCR5; the disease is dengue disease.