In contrast to this innate-like inflammatory transcriptional response associated with progression to DHF, our bioinformatic analysis identified T cell activation molecules and master transcription factors such as MYC, FOXM1 and FOXO1, known to support cell proliferation and govern a range of metabolic processes, as regulators of transcriptional profiles in patients progressing to uncomplicated disease manifestations. This evidence concerns the gene MYC and Dengue hemorrhagic fever.