tSNE analysis and FlowSOM clustering of the CD19+CD20+CD10− MBC pool facilitated the identification of five classical and three atypical MBC sub-populations, including populations of both IgM+IgD+ and class-switched (IgM−IgD−) cells expressing variable levels of the chemokine receptors CCR6, CCR7, CXCR3 and CXCR5 (Fig. 2F), present in the blood of dengue patients at first presentation. Here, CD40LG is linked to dengue disease.