Within these cytobands, a total of 966 genes are located, of which 21 are listed in the COSMIC cancer gene census25 as cancer genes (Supplementary table 12), including proliferation-associated genes CCND1 (11q13.3), CDK4 (12q14.1), MDM2 (12q15) and CCNE1 (19q12). The gene discussed is CDK4; the disease is cancer.