(3) The mechanism by which RIPK1 inhibition increases lysosomal Hsp70.1B levels may be associated with an increase in Hsp70.1B transcription; this occurs via RIPK1 knockdown-mediated exacerbation of ischemic stroke-induced decreases in the cytoplasmic levels of Hsp90 and its interaction with Hsf1, which in turn promotes the nuclear translocation of Hsf1 and increases Hsp70.1B mRNA transcription. This evidence concerns the gene RIPK1 and ischemic stroke.