This result is similar to that of previous meta-analyses on this topic, which included 10 full-text prospective studies showing a sensitivity of 0.77, specificity of 0.76 and AUC of 0.83 for the early diagnosis of cardiac surgery-associated AKI in urine [TIMP-2] × [IGFBP7]40. Here, IGFBP7 is linked to acute kidney injury.