According to the PPI network of DEGs, 13 out of 446 genes displayed an elevated degree of interaction and were upregulated in UC patients: CXCL13, CXCL10, CXCL9, CXCL8, CCL19, CTLA4, CD69, CD163, CCR1, PECAM1, IL7R,TLR8 and TLR2. Chemokines can significantly increase chronic inflammation and intestinal tissue destruction in IBD through their ability to induce chemotaxis and leukocyte activation40. Here, CD163 is linked to inflammatory bowel disease.