Using the deconvo xCell approach, BUB1B expression was also found to be significantly associated with the majority of the 38 immune cell subtypes in diverse tumor types, especially Th2 cell (positive correlation), which demonstrate pro-cancer function via the secretion of interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), and transforming growth factor-β (TGF-β)39. This evidence concerns the gene IL6 and neoplasm.