PCSK9 and triple-A syndrome: Several up-regulated or downregulated genes were visualized in Fig. 1A. DLD and RPS19BP1 were down-regulated and the up-regulated genes contained ZNF575, FHOD1, AKT1S1, CARM1, BTNL8, TMEM252, BRCC3, LSM2, NAPSA, etc. The 50 up-regulated and 50 down-regulated genes with the greatest difference were shown in Fig. 1B. PCSK9 was up-regulated in AAA neck than in normal tissues (p = 0.019) (Fig. 2A).