Since the tumor vasculature is a point-of-entry for anti-tumor immune cells, we have extended this observation by focusing on EC expression of cell adhesion molecules (CAMs) and chemokines after treating primary cultures of murine mammary gland ECs (MGECs) with 5-Aza in the presence or absence of the pro-inflammatory cytokines TNFα or IFNγ. The gene discussed is TNF; the disease is neoplasm.