However, although the present study did a multifaceted pan-cancer analysis of IGFL2, it still has some limitations; First, the study was based on data analysis performed in a database, so its causal argument is less powerful than direct experimental studies, and further mechanistic studies would be beneficial to elucidate the role at the molecular and cellular levels of IGFL2; Second, there are fewer studies on IGFL2 and lack of corresponding results to support it. This evidence concerns the gene IGFL2 and cancer.