After changing the survival index to DFS (Fig. 2B), the statistically significant cancers were PAAD, KIRP, and in the K-M survival curve analysis (Fig. 2B), the elevated expression of IGFL2 in PAAD 3.31 (1.33–8.22) and KIRP 2.32 (1.02–5.27) affected the prognosis. This evidence concerns the gene IGFL2 and pancreatic adenocarcinoma.