IGF family members have been shown to play an important role in a variety of tumorigenesis, such as gastric cancer6, colorectal cancer7, and lung cancer8.Among the relevant studies on the IGFL family, IGFL2 is particularly well represented and deserves analysis.Studies on IGFL2 have found that its expression is upregulated in many cancers, and as a homolog of the IGF family, this pattern may be consistent with IGF family members. The gene discussed is IGF1; the disease is cancer.