However, the mechanism of IGFL2 in various carcinogenesis is unclear and there is a lack of correlation analysis of IGFL2. Herein, we have comprehensively analyzed the expression, prognosis, immunological and biological roles of IGFL2 in cancer based on TCGA database data to explore the multifaceted relationship between IGFL2 and cancer. This evidence concerns the gene IGFL2 and cancer.