In contrast, Toll-like receptor signaling, cell adhesion molecules (CAMs), and JAK/STAT signaling pathways all appeared more frequently in GSEA enrichment results, suggesting that IGFL2 may be involved in related pathways affecting cancer progression.Toll-like receptor signaling is involved in innate and adaptive immune processes and plays an important role in tumorigenesis and progression34, 35. The gene discussed is IGFL2; the disease is cancer.