In terms of gene expression, IGFL2 may be widely elevated as an oncogenic molecule in a variety of cancers, while in prognosis-related analysis, high IGFL2 expression likewise resulted in shorter survival in patients with KIRC,BLCA,KIRP,MESO,PAAD.Notably, in terms of prognosis, IGFL2 was particularly prominent in urologic tumors (KIRC,KIRP,BLCA), and one study found that insulin-like growth factor-II (IGF2) mRNA-binding protein IMP3 expression was closely associated with clinical grade and prognosis of renal clear cell carcinoma23. This evidence concerns the gene IMP3 and cancer.