Also, IGFL2 was significantly associated with the expression of immune checkpoint markers, and reduced methylation of IGFL2 was observed in many types of cancers.In conclusion, this study is the first to analyze the multifaceted relationship between IGFL2 and pan-cancer, and the results of the analysis suggest that IGFL2 may be a new research direction for tumor therapy. Here, IGFL2 is linked to neoplasm.