KMT2A and acute myeloid leukemia: In NSG mice engrafted with PD AML cells harboring MLL1-r (MLL-AF9) and FLT3-TKD, combined therapy with SNDX-5613 and OTX015 for one or for 6 weeks, as compared to each drug alone, was also significantly superior in reducing the AML burden, as well as significantly improving survival of the mice, respectively (Fig. 7C, D).