As shown in Fig. S1A, the MEN1 gene-effect scores were <0.5, highlighting it to be a dependency in several AML cell lines, including those that express MLL-FP (e.g., MOLM13, MV4–11, MonoMac-1 and MOLM14) or mtNPM1 (e.g., OCI-AML3) (Fig. S1A). This evidence concerns the gene KMT2A and acute myeloid leukemia.