As observed in cultured cell lines, co-treatment with SNDX-50469 and OTX015 also displayed synergistic lethal activity against PD AML cells harboring MLL-AF9 plus FLT3-TKD (sample #4, in the oncoplot in Fig. S8A) or mtNPM1 plus FLT3-ITD (Figs. 5G, H and S8B, C). Here, KMT2A is linked to acute myeloid leukemia.