Zernecke et al.48 found that during atherosclerosis, as a self-protective mechanism of the human body, endothelial cells may deliver some miRNA-126-3p-enriched apoptotic bodies to recipient vascular cells to inhibit RGS16 expression and enhance CXCR4 signaling in recipient cells, which will significantly promote SDF-1 expression and recruit EPCs, thereby reducing atherosclerosis. The gene discussed is CXCL12; the disease is atherosclerosis.