CXCL16 and neoplasm: However, the tumor continues to progress (Fig. 4i, Relative Tumor Burden >1.5 fold increase, Day 28 vs Day 14), potentially due to a significant increase of Cluster 0 cells after CXCL16 neutralization (Fig. 4k), suggesting the dynamic nature of the TIME in response to immune modulator CXCL16.