Interestingly, it has been shown that eIF4F-regulated translation of STAT1 mRNA is a critical step of IFN-γ-induced PD-L1 expression on melanoma tumor cells, partially contributing to tumor immune evasion mechanisms57, suggesting a translational significance of modulating elF4F-STAT1 pathway as a potential cancer immunotherapeutic modality in melanoma patients57. The gene discussed is CD274; the disease is melanoma.