To further comprehend the transcriptome of tumor-infiltrating T cells, we identified CITE-CD45+ and CITE-CD3+ TIL cells from our CITE-seq data and clustered them into 10 Seurat Clusters, of which 1 and 2 showed a high expression of Cd3e. There are three major clusters of T cells, Cd8a+ T cells (Cluster 0), Cd4+ T cells (Cluster 1), and Foxp3+ CD4+ T cells (Cluster 2). The gene discussed is CD4; the disease is neoplasm.