The cell viability was significantly higher for each concentration (except 10,000 nM) of BGB-11417 or venetoclax for CLL cells co-cultured with CD40L/APRIL/BAFF fibroblasts compared to CLL cells co-cultured with control fibroblasts (Fig. 2j, k). This evidence concerns the gene TNFSF13 and B-cell chronic lymphocytic leukemia.