Moreover, we found that the patients with thrombocytopenia correlate with anemia and genetic heterogeneity, including 1q21 gain and TP53 deletion, but it is unclear whether the genetic heterogeneity affects thrombocytopenia and whether myeloid progenitor cells are also affected by the microenvironment of myeloma when the progenitor cells differentiate into MKs. Here, TP53 is linked to anemia (phenotype).