TF and neoplasm: For example, binding of galectin-3 to the oncofoetal Thomsen-Friedenreich Galβ1,3GalNAcα-Thr/Ser (TF antigen) on the transmembrane mucin protein MUC1 [18] enhances circulating tumour cell homotypic aggregation and survival [19] and increases tumour cell heterotypic adhesion to vascular endothelium [20].