BCR and cancer: Importantly, increased ABL1 activityshows only modest oncogenic potential, by far less than expressionof the BCR-ABL oncogene.10,11 This is also supportedthrough cancer genome sequence projects.12,13 While amplification is a frequent event in cancers with EGFR kinaseactivation, the gene copy number increase of ABL kinase, as such,is not observed in patient samples.