HCC78 isa NSCLC cell line driven by a SLC34A2/ROS1 fusion and known to exhibitvarious elevated non-RTK activities including ABL1.43 The K562-CML cancer cell line is driven by p210 BCR-ABL.47 Therefore, KSEA enrichment indicates elevatedABL1 activity when probed with ABL literature substrates (not shown).Using our de novo motifs, strong enrichment was foundfor pY-sites that score very high with p210-BCR-ABL in contrast toABL1 and p190-BCR-ABL. The gene discussed is ABL1; the disease is cancer.