Circulating biological tests which are currently used to monitor inflammation and synovial tissue activity in RA include serum C-reactive protein (CRP) which is mainly produced by the liver, and in a more investigative manner cytokines, chemokines, acute serum amyloid A, S100 proteins, the adhesion molecules ICAM-1, VCAM-1 and E-selectin, and the mediators of joint damage, MMPs, osteoprotegerin, and the receptor activator of nuclear factor-κB ligand [2]. The gene discussed is CRP; the disease is rheumatoid arthritis.