Despite the fact that there is an expanding understanding on how TGF-β1 signaling is related with tumor progression in hepatocellular carcinoma, it isn’t evident whether TGF-β1 signaling is restricted to a specific subgroup of patients with hepatocellular carcinoma or is a key driver of hepatocellular carcinoma during the whole tumorigenesis of hepatocellular carcinoma [33]. Here, TGFB1 is linked to hepatocellular carcinoma.