Different growth factors including interleukin family (IL), transforming growth factor (TGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNF-α), transforming growth factor (TGF-β) i.e. (TGF-β1, TGF-β2, and TGF-β3) and some other growth regulators like MYC, JUN Caspase 8, as well are well known for their important role in the disturbance of normal cell progression and turning those cells to cancer cells [31, 32]. The gene discussed is TNF; the disease is cancer.