High CRP concentrations are a common biomarker for infection or systemic inflammation (bacterial, viral or in general), and –already since the early periods of the pandemic– they were described to be in direct association with severe SARS-CoV-2 pneumonia, critical disease development and mortality [74–76], as well as with other major lesions: lungs [77], thrombo-embolism or kidney injury in COVID-19 [78]. This evidence concerns the gene CRP and infection.