For 4-month-old mice that have begun to develop full-thickness retinal atrophy involving RPE, VEGFA is downregulated, and it is speculated that there may be 2 reasons: a decrease in the primary cells that produce VEGFA (glial cells) (44) and vascular compensation that occurs to alleviate the hypoxic state. The gene discussed is VEGFA; the disease is Retinal atrophy.