Moreover, the CSC-cluster A group exhibited prominent enrichment of immune pathways (CD8 T effector, immune checkpoint, and antigen processing pathways) (Supplementary Figure 5G), as well as massive infiltration of immune cells (both pro- and anti-tumor immune cells) (Figure 3G), confirming again the intersectionality of ubiquitination modification regulating cancer stemness and immunity. The gene discussed is CD8A; the disease is cancer.