GFPT1 and breast cancer: In one study, the role of small extracellular vesicles in reprogramming glucose metabolism by increasing hexosamine biosynthesis pathway flux in endothelial cells in response to glutamine fructose-6-phosphate aminotransferase (GFAT) is demonstrated suggesting that inhibiting small extracellular vesicle-mediated GFAT1 secretion from BC cells may serve as novel anti-angiogenetic therapy [121•].