Furthermore, a study investigating the role of CXCL8 secreted by TAMs in urothelial carcinoma showed the infiltration of TAMs in the tumour microenvironment led to the elevation of CXCL8, which in turn promoted the secretion of MMP-9, VEGF, and E-cadherin by BC cells. This evidence concerns the gene CXCL8 and urothelial carcinoma.