In univariable regression analysis with scaled WMH as a dependant variable, cystatin C at Wave 1 (OR per 1 unit increase = 3.32 (95% CI, 1.11 to 9.98), and CKD-EPI eGFRcys at Wave 1 (OR per 1 unit increase = 0.98 (95% CI, 0.97 to 0.99) were significant predictors, whereas CKD-EPI eGFRcre at Wave 1 was borderline significant [OR per 1 unit increase = 0.99 (95% CI, 0.97 to 1.00)]. The gene discussed is CST3; the disease is chronic kidney disease.