Previous studies have demonstrated that Nav1.1 is predominantly clustered in the axon initial segments of parvalbumin‐positive inhibitory interneurons, and loss of function of Nav1.1 in inhibitory interneurons results in E/I imbalance with the reduced inhibitory tone, leading to a greater seizure susceptibility in patients with DS compared with healthy people.33, 34, 35. The gene discussed is PVALB; the disease is Dravet syndrome.