Studies have reported that the variants in ZP1(MIM: 195000), ZP2 (MIM: 182888), and ZP3 (MIM: 182889) affect the formation of zona pellucida and result in female infertility (Huang et al, 2014; Liu et al, 2017; Dai et al, 2019), but there is no convincing evidence to prove that ZP4 (MIM: 613514) variant responsible for female infertility. The gene discussed is ZP2; the disease is female infertility.