Other signaling cascades associated with tau and/or amyloid dysregulation include cyclin‐dependent kinase 5 (CDK5),45, 48 glycogen synthase kinase‐3β pathways (GSK‐3β),45, 48 protein phosphatase 2A (PP2A) signaling49 as well as Wingless/Integrated (Wnt), mitogen‐activated protein kinase (MAPK), and c‐Jun N‐terminal kinase (JNK) signaling, which are known to be altered in epilepsy.45, 48, 49, 51, 52, 53, 54. The gene discussed is PTPA; the disease is epilepsy.