Thus, to assess the extent of AD‐like pathology and its relation to cognitive dysfunction in epilepsy, we measured the relative abundance of p‐tau and Aβ proteins in brain biopsies surgically resected from 12 patients diagnosed with refractory epilepsy and correlated these to neurophysiological scores for full‐scale intelligence quotient (FSIQ) for each case. The gene discussed is MAPT; the disease is epilepsy.