IRGM1 can also interact with NOD2 [63], and is reported to interact with the inflammasome NLRP3 and ASL proteins to prevent their oligomerisation, as well as with p62 to mediate p62-dependent selective autophagy of NLRP3 and ASL, thus suppressing IL-1β maturation, pyroptosis and protection against caspase-1 activity in a DSS-colitis model [102]. The gene discussed is ASL; the disease is colitis.