Macrophage RORα fails to upregulate as hyperglycemic inflammatory microenvironment induced insulin‐like growth factor 1 (IGF1) scarcity and 5′‐AMP‐activated protein kinase (AMPK) signalling inactivation in the early stage of bone defect repair from DM rats, which causes regeneration deficiency severely. The gene discussed is IGF1; the disease is diabetes mellitus.