MAPT and early-onset autosomal dominant Alzheimer disease: For example, a recent investigation in the DELCODE (Jessen et al., 2018) revealed that the precuneus novelty response exhibits an inversed U‐shaped response pattern across the Alzheimer's disease risk spectrum from healthy older adults to individuals at risk (SCD, MCI) to patients with early‐stage Alzheimer's dementia (Billette et al., 2022), and it may be promising to look at the relationship to local tau pathology (Düzel et al., 2022).