Importantly, transduction of a shRNA-resistant-YME1L (“shR-YME1L”) restored YME1L and Gαi1 expression as well as the Akt phosphorylation in P1 glioma cells expressing the lv-shYME1L-seq1 (Fig. 2L). The gene discussed is YME1L1; the disease is central nervous system cancer.