Expression of RTKs, including epidermal growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor α (PDGFR α) as well as Gαi3 was not significantly changed in P1 glioma cells with YEM1L shRNA/KO (Fig. 2D). Here, EGFR is linked to central nervous system cancer.