In addition, Fig. 1M showed that 5-ethynyl-2ʹ-deoxyuridine (EdU)-positive nuclei ratio was dramatically decreased in YME1L-silenced and koYME1L glioma cells, supporting the anti-proliferative activity by YME1L depletion in primary glioma cells. This evidence concerns the gene YME1L1 and central nervous system cancer.