Conversely, in the YME1L-overexpresed P1 glioma cells (OE-YME1L-sL1 and OE-YME1L-sL2, see Fig. S4), Gαi1 mRNA (Fig. 2E) and protein (Fig. 2F) levels were significantly increased, and Akt activation was augmented (Fig. 2F). The gene discussed is YME1L1; the disease is central nervous system cancer.