Furthermore, an examination of mitochondrial lysates isolated from fresh human glioma tissues of four representative patients (Patients 1–4) confirmed that YME1L was enriched in the mitochondria fraction (Figs. 1I and S1B), as indicated by VDAC1 (voltage-dependent anion-selective channel 1), a mitochondrial marker protein (Figs. 1I and S1B). This evidence concerns the gene YME1L1 and central nervous system cancer.