EZH2 and diffuse large B-cell lymphoma: The “hotspot” gain-of-function mutations at Y641 (Y641X, X = F, N, C, S, or H) within the catalytic domain of EZH2 were found in 22% of patients with GCB-type diffuse large B-cell lymphoma (DLBCL) and 7% of patients with follicular lymphomas (Morin et al., 2010; Yap et al., 2011).