Loss-of-function mutations in skin, urothelial, bladder, lung, head and neck, esophagogastric, colorectal, small bowel cancers (Fagan and Dingwall, 2019), andnon-Hodgkin lymphoma (MLL4 R5432W) (Li et al., 2016). The gene discussed is KMT2B; the disease is small intestine carcinoma.