NSD2 and neoplasm: Remarkably, the “hotspot” E1099K mutation within the catalytic domain of NSD2 is found in 14% of pediatric ALLs (Jaffe et al., 2013) and other neoplasms, such as lung adenocarcinoma, colon cancer, and thyroid tumors (Imielinski et al., 2012; Husmann and Gozani, 2019).