PDK1 and glioblastoma: Activation of receptor tyrosine kinase and expression of oncogenic K-Ras and B-Raf in glioblastoma cells suppressed mitochondrial metabolism of glycolysis-derived pyruvate through phosphoglycerate kinase 1 (PGK1)-mediated phosphorylation and inhibition of pyruvate dehydrogenase kinase 1 (PDHK1), with a concomitant increase in glutaminolysis (Li et al. 2016).