It has been reported that TGF-β1 is strongly positively correlated with macrophage in HCC.33 Macrophages M0 can secrete a large amount of TGF-β1.33 In our study, it was found that LAMA4 affected the progress of HCC by regulating TGF-β1. This evidence concerns the gene LAMA4 and hepatocellular carcinoma.