CD4 and hepatocellular carcinoma: The previous analysis showed that Tregs cells are abundant in HCC tumors and are a subset of CD4+ T cells, a type of lymphocyte with high immunosuppressive properties.36 They suppress the immune response by inhibiting CD8+ T cell effector functions and directly promote tumor escape through a variety of contact-dependent and non-contact mechanisms.37 In HCC, neutrophils can recruit macrophages and Tregs into HCC by releasing cytokines, thereby promoting tumor progression and developing resistance to sorafenib.38