Cir_POLA2 has been reported as an oncogene of lung cancer.19 It has been found that overexpression of Cir_POLA2 can promote the proliferation of acute myeloid leukemia cells.20 Circ_POLA2 may upregulate the G protein subunit beta 1 (Notch pathway-related molecules) by serving as an endogenous competing RNA for miR-326.14.21 Guanine nucleotide regulatory protein (G protein) is the core of normal liver cell function and is related to the occurrence and progression of liver disease. This evidence concerns the gene GNAS and lung cancer.