It has been reported that the upregulation of Tregs is a predictor of adverse outcomes in HCC patients.34 It has been reported that Tregs promote the migration and invasion of liver cancer cells through epithelial-to-mesenchymal transition induced by TGF-β1.35 Neutrophils are the most common white blood cells in circulation. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.