NOP56 and amyotrophic lateral sclerosis: Previous studies have shown that the somatic heterogeneity of the repeat sizes is quite common in similar repeat expansion disorders, such as ALS/FTD caused by the C9orf72 and SCA10 caused by the ATXN10. (Matsuura et al., 2004; Ebbert et al., 2018) However, the somatic heterogeneity of SCA36 has only been mentioned in the literature and has not been described in detail.