In summary, we constructed a new risk score model using machine learning arithmetic based on 11 prognostic-related CSRGs (POLR2K, PYCARD, HSPA8, NFKBIE, EIF2AK2, JUN, CCL5, IL18, PRKDC, IFNG, IL33) to effectively predict prognosis and immunotherapy benefits in breast cancer patients. Here, IL33 is linked to breast cancer.