In summary, we constructed a new risk score model using machine learning arithmetic based on 11 prognostic-related CSRGs (POLR2K, PYCARD, HSPA8, NFKBIE, EIF2AK2, JUN, CCL5, IL18, PRKDC, IFNG, IL33) to effectively predict prognosis and immunotherapy benefits in breast cancer patients. This evidence concerns the gene HSPA8 and breast carcinoma.