Univariate Cox regression analysis showed that AFP, BCLC stage, degree of tumor differentiation, microvascular invasion, multiple nodules, satellites, TNM stages, tumor size, and hsa-miR-137, hsa-miR-3180, hsa-miR-378i, and hsa-miR-5589-5p expression correlated significantly with HCC prognosis (p < 0.05). This evidence concerns the gene AFP and neoplasm.