Almost half of these genes (purple-colored genes) were enriched in Hepatitis B, Hepatitis C and Hepatocellular carcinoma pathways including MYC, CD81, CDKN1A, IGF1R and so on (Lin et al., 2010; Li et al., 2020; Ngo et al., 2021) which were reported in Hepatocellular carcinoma. The gene discussed is CDKN1A; the disease is hepatitis B virus infection.