IFNG and cancer: The findings demonstrated a considerable enrichment of NK cell and type II interferon (IFN-γ) response, as well as a particularly pronounced survival advantage for ferroptosis cluster A. It has been proved that NK cells directly kill tumor cells through cytolytic granules and act synergistically with other immune cells through proinflammatory cytokines and chemokines, which is closely related to the prognosis of cancer patients (72–74).