Smc4, a core subunit of condensing, has been reported to be associated with a variety of tumors, such as hepatocellular carcinoma (47), prostate cancer (48), and lung adenocarcinoma (49), and activated TGFβ/Smad signaling has been reported to promote the aggressive phenotype of glioma (50). Here, TGFB1 is linked to central nervous system cancer.