IDH1 and alpha thalassemia spectrum: IDH, TP53, alpha-thalassemia/mental retardation, X-linked (ATRX) mutations, MGMTp methylation, and 1p/19q codeletion have been considered clinically meaningful markers of LGG (5–8), and especially IDH mutation, 1p/19q codeletion, and MGMTp methylation status are closely related to diagnosis and prognosis, which are crucial for postsurgical treatment such as adjuvant chemotherapy and adjuvant radiotherapy (9).