In HNA patients with benign lesions histopathological examination revealed 33 adenomas, 8 ACTH-independent macronodular adrenal hyperplasia (AIMAH), 3 post-hemorrhage changes, 2 cystic lesions and 2 cases of pheochromocytoma. Here, POMC is linked to hereditary pheochromocytoma-paraganglioma.