We first characterized the localization of endogenous KRAS in fixed and permeabilized ex vivo cultured CRC matched mucosa-tumor pair which revealed that tumors with somatic KRAS p.Gly12Val activating mutations show higher inner plasma membrane KRAS localization (net-like pattern) compared to its matched mucosa (where KRAS was wild-type) (Figures 1E, F). The gene discussed is KRAS; the disease is neoplasm.