Numerous studies, both retrospective using previous ACE2 genetic information from databanks and “wet-laboratory” experiments, have examined the SNPs in the ACE2 gene with a common interest in ascertaining their implication on the severity and or susceptibility, especially on various cardiovascular diseases (CVD), hypertension, stroke [14, 56], and currently COVID-19 [52, 53]. This evidence concerns the gene ACE2 and hypertensive disorder.