Importantly, deletion of Foxo1 in the heart, prevented cardiac hypertrophy and steatosis, in HFD-fed mice (Battiprolu et al., 2012), and additionally, Foxo1 KO blunted TAC (transverse aortic constriction)-induced cardiac hypertrophic growth (Ferdous et al., 2020). Here, FOXO1 is linked to steatosis.