BGLAP and congenital heart disease: Being evolutionarily conserved, the implication that Opa and Oc are pre-gastrulation cell specification factors is potentially relevant to higher species, including humans, both in the interrogation of nascent embryonic development and investigation of congenital disease, e.g., autism (El Hayek et al., 2020), epilepsy (Acampora et al., 2000; Montalta-He et al., 2002), and congenital heart disease (Ware et al., 2004).