–Negative TPHA/VDRL, toxocariasis, leptospirosis, bartonella, tularemia, filariosis, CMV, HIV, Coxsackie virus, EBV enterovirus, and rubeola.1.Negative ANA, C3/C4, anti-ECT, CRP, anti-DNA antibody, ESR, and CRP2.Anterior chamber paracentesis negative for malignancy, negative PCR for HSV, CMV, VZV3.EOG: Arden ratio: 210%/200%4.mERG: macular dysfunction OS > OD5.Brain MRI: stable hypersignal micronodular lesions of white matter. The gene discussed is ESR1; the disease is leptospirosis.