IGFBP7 and acute kidney injury: H. M. Jia et al. (71) conducted a systematic review evaluating the effects of urinary tissue inhibitor of metalloproteinase-2 [TIMP-2] and insulin-like growth factor-binding protein 7 [IGFBP7] on the early diagnostic value of acute kidney injury, which included 9 eligible published studies with 1,886 cases.