The underlying molecular mechanism may involve acetate, propionate, or butyrate promoted lipid oxidative metabolism and body weight reduction via upregulating adenosine monophosphate‐activated protein kinase (AMPK) and downregulating peroxisome proliferator‐activated receptor‐γ (PPARγ) in preventing obesity (Besten et al., 2015). The gene discussed is PPARG; the disease is obesity disorder.