The underlying molecular mechanism may involve acetate, propionate, or butyrate promoted lipid oxidative metabolism and body weight reduction via upregulating adenosine monophosphate‐activated protein kinase (AMPK) and downregulating peroxisome proliferator‐activated receptor‐γ (PPARγ) in preventing obesity (Besten et al., 2015). This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.