TJP1 and obesity due to melanocortin 4 receptor deficiency: Moreover, Mujawdiya et al. (2020) found that mango seed kernel extract reversed intestinal hyperpermeability, as measured by ZO‐1 and claudin‐1, and improved obesity‐related metabolic symptoms, whereas a high‐fat diet reduced the expression of tight junctions, and consequently led to metabolic disease in obese mice.