The study also has implications for radiation treatments in other tumor predisposition syndromes, beyond NF1 where a high-risk of MPNST and high-grade glioma is already known after childhood irradiation,30 and especially for SMARCB1-related-schwannomatosis in which MPNST is already reported.31 The gene discussed is NF1; the disease is BAP1-related tumor predisposition syndrome.