Although malignant transformation of schwannomas post-irradiation is uncommon it is noteworthy that almost half the cases following VS radiation treatments occurred in NF2 patients whilst probably less than 5% of the cases treated were NF2 patients.11 There are concerns not just about the potential increased risks of malignant progression (MP) in the often, multifocal tumors of NF2 but also in the induction of new malignancies or indeed meningiomas and schwannomas in the radiation volume (field) in this tumor-predisposing condition.12 The gene discussed is NF2; the disease is neoplasm.